214 Studies, 21 Guidelines: Largest Review on Transgender-Youth Medicine Finds Insufficient Evidence for Medicalization

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The review stated that there is insufficient evidence to demonstrate the long-term benefits of medicalizing children who want to identify as a different gender.

England may be the third country to withdraw from a “gender-affirming” treatment pathway due to recommendations from a long-awaited report.

In April, the country published the Cass Review, “most comprehensive summary on transgender-youth medicine,” psychologist Erica Anderson, who identifies as transgender and has a doctorate in clinical psychology, told The Epoch Times.

The review, chaired by Dr. Hilary Cass, British honorary physician, consultant in pediatric disability, and former president of the Royal College of Pediatrics and Child Health, stated that there is insufficient evidence to demonstrate the long-term benefits of medicalizing children who want to identify as a different gender. Instead, the review recommends focusing on psychotherapy.

For some clinicians and researchers, this recommendation was a long time coming. Others are concerned that it potentially threatens medicalization—currently the primary treatment—for gender-incongruent youths.

The National Health Service (NHS) England, which commissioned the report in 2020, stated it would be committed to following through on the recommendations.

“[The Cass Review] final report will not just shape the future of healthcare in this country for children and young people experiencing gender distress but will be of major international importance and significance,” the statement read.

Eight days after the Cass Review’s release, Scotland’s health boards announced a pause on new prescriptions for puberty blockers and cross-sex hormones as they gather evidence to support the safety and clinical effectiveness of these medications

‘End of the Era’

The Cass Review is based on the work of 237 papers, including 214 studies, 21 guidelines, and two position statements, which covered data of over 113,000 children and young people. The authors also analyzed anonymized data from over 3,700 children diagnosed with gender dysphoria, survey responses from professionals, and numerous interviews and testimonies from stakeholders of the issue.

The review team commissioned researchers at the University of York to conduct systematic reviews of these papers and get feedback by interviewing young gender-incongruent children, their parents, and clinicians.

By Marina Zhang

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