Drug Used to Treat COVID-Related Loss of Smell Found Ineffective: Study

Clinical trial results were manipulated by the manufacturer to exaggerate the drug’s effectiveness, especially for off-label use.

For many COVID-19 survivors, the inability to smell life’s aromas is an unseen affliction that lasts months after recovering from the infection. This hidden impairment robs them of a primal sense, leaving them disconnected.

Hope emerged when doctors prescribed gabapentin to treat COVID-related smell loss. But new research has deflated expectations, finding in a double-blinded, placebo-controlled clinical trial that the medication is ineffective.

Gabapentin Falls Short in 8-Week Trial

The trial ran from January 2022 to February 2023, involving adults with at least three months of smell dysfunction after COVID-19 infection. Those with other causes for smell disorders or inability to take gabapentin were excluded.

Researchers enrolled 68 participants, randomly assigning 34 to a placebo group and 34 to an oral gabapentin treatment group. All patients were exposed to the maximum tolerable dose for four weeks. After that, doses were adjusted to the highest tolerable amount, maintained during an eight-week fixed-dose phase. In the gabapentin group, 56 percent received the maximum dose of 3,600 milligrams daily.

After completing that phase, 41 participants were tapered off and monitored for four more weeks.

The researchers found no clinically meaningful difference between the gabapentin and placebo groups over the entire duration of the trial.

โ€œChanges in subjective olfactory function, objective odor identification, and olfactory-related quality of life were neither clinically meaningful nor statistically significant,” the trial researchers wrote.

However, the authors noted that the findings applied only to an eight-week treatment period. Longer treatment may yield different results.

Side Effects

The most common adverse effects were fatigue, reported by 10 in the gabapentin group and 11 in the placebo group, along with expected side effects like dizziness, weight gain, and brain fog in the gabapentin group.

No serious adverse events occurred in either group.

Byย George Citroner

Read Full Article on TheEpochTimes.com

The Epoch Times
The Epoch Timeshttps://www.theepochtimes.com/
Tired of biased news? The Epoch Times is truthful, factual news that other media outlets don't report. No spin. No agenda. Just honest journalism like it used to be.

Columns

Viewers like you

There is no constitutional authority for any spending on public broadcasting โ€“ period. Any questions: See Article 1, Section 8 of the U.S. Constitution.

Beyond the Trump-Musk fallout?

We are witnessing an unprecedented, unhinged Democrat effort to use lawfare, big Democrat donors, street theater, congressional disruptions, potty-mouth videos, the administrative state, the legacy media, and discredited pollsters to stop the Trump agenda.

Trans-wormal

No worm ever said "I am anthropomorphizing, I am a butterfly" to a toad or flock of geese and expected acknowledgement and support.

In Greenlandโ€™s Icy Capital, Past Troubles Haunt Hopes for the Future

As geopolitical realities and ongoing economic growth raise the stakes, U.S. interest in Greenland and the dream of independence may change things in a big way.

How a Chinese Government Statistician Was Forced to Report Fake Data

Chinese local govt employee produced a non-authorized report on bees and was visited by police and threatened with being sent to a mental hospital.

News

Supreme Court Sides With DOGE in Social Security, Records Cases

The Supreme Court handed DOGE two big wins late on June 6 in its effort to reduce the size of the federal government.

Kilmar Abrego Garcia Returns to US to Face Criminal Charges

Kilmar Abrego Garcia, a citizen of El Salvador, is on his way back to the US, where he will face criminal charges for allegedly smuggling illegal immigrants.

White House Adviser Gives Update on DOGEโ€™s Future Amid Muskโ€“Trump Spat

A top White House adviser said DOGEโ€™s work will likely continue amid a spat between its former chief, Elon Musk, and President Donald Trump.

Trump Administration Asks Supreme Court to Allow Dismantling of Education Department

Trump admin asked Supreme Court to allow it to resume dismantling U.S. Dept of Education, following a lower courtโ€™s previous order halting process.

FTC Warns of Rising Student Loan Scams, Says Fraudsters Took Millions From Borrowers

FTC is warning borrowers to steer clear of student loan debt-relief scams, after shutting down group of companies that allegedly charged millions in illegal fees and left customers worse off.

Walmartโ€™s Drone Delivery Coming to 5 More US Cities

Walmart is set to launch its drone delivery service in five more U.S. cities: Atlanta, Charlotte, Houston, Orlando, and Tampa, the company.

Court Orders Trump Administration to Restore AmeriCorps Funding to States

Federal court ordered Trump admin to restore AmeriCorps funding to states. The ruling comes as part of a lawsuit filed by 24 states and DC.

Tax Deductions You Can Take Without Itemizing

Itโ€™s not always beneficial to itemize. With IRSโ€™s current standard deduction for 2025 most Americans who canโ€™t itemize go with standard deduction.
spot_img

Related Articles