ICYMI: Dr. Rand Paul Introduces Risky Research Review Act to Oversee Gain-of-Function Research Funding

Contact Your Elected Officials

WASHINGTON, D.C. โ€“ Yesterday, U.S. Senator Rand Paul (R-KY), Ranking Member of the Senate Homeland Security and Governmental Affairs Committee, introduced the Risky Research Review Act, a first-of-its-kind proposal to establish a Life Sciences Research Security Board within the Executive Branch. This independent board will oversee the funding of gain-of-function research and other high-risk life sciences research that potentially poses a threat to public health, safety, or national security.

The Life Sciences Research Security Board will serve as an independent body responsible for thoroughly evaluating gain-of-function research and other studies involving the collection, surveillance, genetic modification, or synthetic creation of potential pandemic pathogens. Currently, the funding and study of life sciences research lack sufficient government oversight, allowing American taxpayer dollars to be spent without appropriate checks. Dr. Paulโ€™s legislation establishes a stringent review process for the board to assess high-risk research and decide whether tax dollars should support specific research proposals.

The Risky Research Review Act will:

  1. Establish an Independent Oversight Board: Form a Life Sciences Research Security Board dedicated to protecting public health, safety, and national security by evaluating and issuing binding determinations on high-risk life sciences research proposals seeking federal funding.
  2. Define High-Risk Research: Specify high-risk life sciences research as studies with potential dual-use applications or those that could pose a threat to public health, safety, or national security, including gain-of-function research.
  3. Ensure Board Independence: Position the board as an independent agency within the Executive Branch, consisting of one executive director, five non-governmental scientists, and two national security experts, each serving up to two four-year terms appointed by the President and confirmed by the Senate.
  4. Restrict Funding Without Approval: Prohibit federal agencies from awarding funding for high-risk life sciences research without board approval.
  5. Mandate Majority Vote: Require a majority vote of board members to approve high-risk life sciences research.
  6. Empower the Board: Authorize the board to compel agencies to turn over necessary information and records, including classified information.
  7. Demand Full Disclosure: Require grant applicants to declare if their research falls under high-risk life sciences categories or involves select agents or toxins.
  8. Automatic Referral: Mandate that all positive attestations are automatically referred to the board.
  9. Continuous Subcontract Disclosure: Enforce continuous disclosure of subcontracts or subawards, with agencies required to submit these disclosures to the board.
  10. Annual Reporting: Oblige the board to submit an annual report to the appropriate congressional committees and publish it online, summarizing determinations, findings, and information about entities and sub-awardees involved in high-risk life sciences research.

You can read S.4667, the Risky Research Review Actย HERE.

See below for statements of support for the Risky Research Review Act:

โ€œThis is a very important bill which when implemented will ensure national security is prioritized when making US life science funding decisions. If we had this bill in place ten years ago we could have prevented the Covid pandemic.โ€ โ€“ Dr. Redfield, M.D., Former Director (2018-2021), Centers for Disease Control and Prevention, U.S. Department of Health and Human Services

โ€œThe Risky Research Review Act is a great step forward toward the goal of protecting the American people from scientists conducting the kinds of dangerous experiments that likely led to the covid pandemic. If the bill is passed, scientists will no longer have carte blanche to regulate themselves to sign off on such experiments. It is far past time for the people who pay for the scientistsโ€™ work to have a voice in the risks they take on the peoplesโ€™ behalf.โ€ โ€“ Jay Bhattacharya, M.D., PH.D., Professor of Health Policy, Stanford University

โ€œResearch with pandemic risks can result in millions of deaths and trillions in economic damage. Research with such extreme outcomes must be subject to external and independent oversight. A responsible government would put in place measures and systems to ensure high visibility into such research and accountability when lab-based outbreaks ensue.โ€ โ€“ Dr. Alina Chan is a molecular biologist at the Broad Institute of M.I.T. and Harvard, and a co-author of โ€œViral: The Search for the Origin of Covid-19.โ€

โ€œI have closely reviewed the legislative proposal, and I strongly support the legislative proposal. The gaps in current US oversight of research on potential pandemic pathogens place the US at risk of research-related pandemics, with medical, economic, and national-security impacts as disruptive and damaging as, or even more disruptive and damaging than, those of the COVID-19 pandemic.  Addressing the gaps in oversight is essential and urgent. The legislative proposal sets forth an approach to close the gaps in oversight and, appropriately, addresses only the small subset of biomedical research that poses highest risk (with definitions tailored to cover less than 0.1% of biomedical research) and balances the need for strengthened oversight with the need not to constrain biomedical research that could provide positive medical, industrial, or national-security value.  The proposal sets forth an approach that will close the gaps with minimal costs and minimal adverse impacts. Thank you in advance for your leadership in considering and approving this legislation.โ€ โ€“ Richard H. Ebright, Board of Governors Professor of Chemistry and Chemical Biology, Rutgers University, Laboratory Director, Waksman Institute of Microbiology at Rutgers University

โ€œThe Risky Research Review Act is historic. For the first time, the risk of a laboratory accident starting a pandemic worse than COVID-19, which killed over one million Americans, is being taken out of the hands of the scientists doing the work and placed in an independent agency. Senator Paul should be commended for his leadership in putting forward this legislation. Historians will compare this to the 1946 establishment of the Atomic Energy Commission by President Truman, which had the same goal: make sure advanced technology, in that case atomic energy, are only used for the benefit of the American citizens. COVID was a bipartisan killer; this bill should be strongly supported by both parties.โ€ โ€“ Steven Quay, M.D., PH.D., Chief Executive Officer Atossa Therapeutics, Inc. and Former Faculty, Stanford University School of Medicine

โ€œSenator Paulโ€™s legislation to establish the Risky Research Review Board is both necessary and urgent. It addresses major shortcomings in both the current guidelines for oversight of high-risk pathogen research and the new guidelines scheduled to take effect in 2025. Critically, the legislation would replace decades of self-regulation with an independent oversight mechanism for federally funded high-risk pathogen research, the first of its kind. This is much-needed, common-sense legislation that, unlike the existing guidelines and those scheduled to take effect in 2025, will safeguard the public from the threat of lab-generated pandemics.โ€ โ€“ Bryce Nickels, Co- Founder, Biosafety Now and Professor of Genetics, Rutgers University    

โ€œSenator Rand Paul has introduced an important new bill for the oversight of potentially dangerous gain-of-function research. I highly commend the Senator for this critical effort to improve the safety of the USโ€™ biodefense enterprise.โ€ โ€“ Meryl Nass, M.D.

Additionally, the bill is endorsed by Neil Harrison, Ph.D., Columbia University in his personal capacity.

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