A growing list of food sources, including shrimp, pigs, and beef, are being targeted by mRNA gene therapy technology, and the risks are entirely unknown.
Shrimp have become the latest addition to a growing list of food sources targeted by mRNA gene therapy technology. An Israeli company seeking to bring mRNA vaccines to shrimp farming has raised $8.25 million from a group of venture capitalists to promote and improve animal health in marine species through its orally administered RNA-particle platform.
ViAqua, a biotechnology company, created an RNA-based vaccine product that uses ribonucleic acid interference (RNAi) to manipulate gene expression in shrimp. RNAi is a biological process where RNA molecules are used to inhibit gene expression or translation by neutralizing targeted mRNA molecules.
The vaccine comes in the form of a coated feed supplement designed to enhance resistance to white spot syndrome virus (WSSV)—a viral infection that causes an annual loss of about $3 billion and a 15 percent reduction in global shrimp production. ViAqua suggests RNA molecules can inhibit the expression of genes that cause disease with every meal containing its coated product.
According to a 2022 proof-of-concept study, the nanovaccine was roughly 80 percent effective in a lethal WSSV challenge model and exhibited excellent in vivo safety profiles. Yet the risks of altering gene expression in shrimp and the effects of consuming vaccinated shrimp are unknown.
“Oral delivery is the holy grail of aquaculture health development due to both the impossibility of vaccinating individual shrimp and its ability to substantially bring down the operational costs of disease management while improving outcomes,” said Shai Ufaz, CEO of ViAqua in a press release. “We are excited to bring this technology to market to address the need for affordable disease solutions in aquaculture.”
ViAqua plans to begin production in India in 2024 and believes its technology has numerous applications in aquaculture and beyond, according to their press release.
mRNA Vaccines Are Already Used in Pigs
The aquaculture industry is not the only market being targeted with mRNA vaccines. Genvax Technologies, a startup creating mRNA vaccines for animals, in 2022 secured $6.5 million in funding to develop a self-amplifying mRNA (saRNA) platform that allows for rapid development of a herd or flock-specific vaccine matched 100 percent to the circulating variant at the root of a disease outbreak.
