FDA Leaders, Other Scientists Say Most People Don’t Need Vaccine Boosters

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An international group of vaccine experts, including officials from the Food and Drug Administration (FDA) and World Health Organization (WHO), said that there is no evidence to suggest that the general population needs COVID-19 vaccine booster shots.

The authors warned that if booster shots are introduced too soon, they may cause more side effects in the general population, including myocarditis or Guillain-Barre syndrome. Should that occur, the researchers said, it would create even more problems with vaccine acceptance in the general population.

The paper was published Monday in The Lancet medical journal and was co-authored by Marion Gruber and Phil Krause, two top FDA officials in charge of regulating and approving vaccines. Both Gruber and Krause are slated to depart the FDA in the coming weeks, the agency confirmed about two weeks ago.

The Lancet paper’s authors said that available COVID-19 vaccines are able to offer strong protection against severe COVID-19 cases and symptoms. They noted that protection against symptomatic infection from the Delta variant has dropped.

But, they added that “current evidence does not … appear to show a need for boosting in the general population, in which efficacy against severe disease remains high.”

“Even if boosting were eventually shown to decrease the medium-term risk of serious disease, current vaccine supplies could save more lives if used in previously unvaccinated populations,” the authors added.

Booster shots could lead to more harmful side effects in the general population, which is a poorly understood phenomenon, they cautioned.

“There could be risks if boosters are widely introduced too soon, or too frequently, especially with vaccines that can have immune-mediated side-effects (such as myocarditis, which is more common after the second dose of some mRNA vaccines, or Guillain-Barre syndrome, which has been associated with adenovirus-vectored COVID-19 vaccines ),” the study said.

If “unnecessary boosting causes significant adverse reactions,” such as the aforementioned side-effects, the authors said, “there could be implications for vaccine acceptance that go beyond COVID-19 vaccines.”

By Jack Phillips

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