Risk of Cardiac Death Tripled for Young Women Following AstraZeneca COVID-19 Vaccination: Study

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The risk of sudden cardiac death in young women more than tripled following an AstraZeneca COVID-19 shot, according to a study using Englandโ€™s official data published on Monday.

Vahรฉ Nafilyan, senior statistician at the Office for National Statistics (ONS), said researchers found โ€œreceiving a first dose of a non-mRNA vaccine was associated with an increased risk of cardiac death in young women.โ€

There was no evidence that the risk of death in young people increased following vaccination with mRNA shots, such as those produced by Pfizer-BioNTech and Moderna.

The ONS compared deaths of people aged between 12 and 29 that occurred within 12 weeks of COVID-19 vaccinationโ€”the so-called risk periodโ€”to those that occurred at all times after the risk period, to estimate the risk of death following vaccination.

After cross-referencing the deaths with records of COVID-19 vaccination and test results, the ONS said there had been โ€œno significant increase in cardiac or all-cause mortalityโ€ within 12 weeks of receiving COVID-19 vaccines.

However, a breakdown of data showed that the risk of cardiac death among young women was three times higher in the 12 weeks following any dose of non-mRNA vaccination, compared with the longer-term risk.

When only the first dose was included, young womenโ€™s risk of cardiac death become 3.5 times higher within 12 weeks of vaccination.

But the ONS also noted that the subgroup who received non-mRNA vaccines โ€œwas more likely to be clinically vulnerable and may be at greater risk of adverse events following vaccination than the general population.โ€

It also said the absolute number of deaths was small.

โ€œAccording to the statistical model, 11 out of the 15 cardiac deaths in young women that occurred within 12 weeks of a first dose of a non-mRNA vaccine were likely to be linked to the vaccine; this corresponds to 6 cardiac-related deaths per 100,000 females vaccinated with at least a first dose of a non-mRNA vaccine,โ€ the ONS said.

By Lily Zhou

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