Two Men Die After Getting Moderna Jab From ‘Contaminated Batch’ in Japan

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Two people have died in Japan after receiving Moderna’s COVID-19 vaccine amid an ongoing investigation into reports of contamination related to three batches of vaccines that amount to 1.63 million doses, the country’s health ministry said on Saturday.

Both men, in their 30s, died in August within days of receiving their second dose of the Moderna shot, Japan’s Ministry of Health said in a news release. The men each received a shot from one of three manufacturing lots suspended earlier this week.

Moderna previously has described the contamination reports as a “particulate matter” that did not pose a safety or efficacy issue.

The U.S.-based drugmaker and Takeda Pharmaceutical said in an Aug. 28 joint statement that they have been notified of the deaths in Japan, calling it a “tragic event”—noting that there is currently no evidence that the Moderna jab caused these deaths.

“At this time, we do not have any evidence that these deaths are caused by the Moderna COVID-19 vaccine, and it is important to conduct a formal investigation to determine whether there is any connection,” the companies said.

Moderna and Takeda, a drugmaker distributing Moderna vaccines in Japan, launched an investigation together with the Japanese Ministry of Health, Labour and Welfare (MHLW) into the deaths.

“The investigation is being conducted with the greatest sense of urgency, transparency and integrity and is of the highest priority,” according to the joint statement. “Takeda and Moderna will keep the public informed as we learn more.”

According to The Asahi Shimbun, citing health officials, “foreign materials” were found in at least 390 doses—or 39 vials—of the Moderna vaccine, coming from eight vaccination sites. Takeda has since requested Moderna to urgently conduct a thorough investigation to determine the nature of the foreign substance.

At first, one batch with a total of 565,400 doses was discovered and put on hold over contamination concerns. Two more batches were found later and also put under investigation. The country’s health ministry requested distribution centers not to use the 1.63 million vaccine doses. The vaccines were shipped to more than 800 centers nationwide.

Moderna said contamination could be due to a manufacturing issue on one of the production lines at its contract manufacturing site in Spain, operated by Madrid-based Rovi.

By Lorenz Duchamps

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